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48,XXYY syndrome is a condition related to the X and Y chromosomes (the sex chromosomes). People normally have 46 chromosomes in each cell.Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics.
Often, symptoms are milder in mosaic cases, with regular male secondary sex characteristics and testicular volume even falling within typical adult ranges. [42] Another possible mosaicism is 47,XXY/46,XX with clinical features suggestive of KS and male phenotype, but this is very rare.
XXXY syndrome is therefore often referred to as 48,XXXY. There is a wide variety of symptoms associated with this syndrome, including cognitive and behavioral problems, taurodontism, and infertility. [3] [2] This syndrome is usually inherited via a new mutation in one of the parents' gametes, as those affected by it are usually infertile. It is ...
Health Canada approved sale of Seroquel XR on 27 September 2007. [93] In October 2008, the FDA approved Seroquel XR for the treatment of bipolar depression and bipolar mania. In December 2008, Biovail announced that the FDA had accepted the company's ANDA to market its own version of sustained-release quetiapine. [94]
[1] [2] Adult XXXYY men have generally been reported as having moderate to severe intellectual disability; [1] moderate intellectual disability is defined by an adult cognitive capacity similar to that of a six- to eight-year-old and the ability to acquire basic living and employment skills with support, while the severe form is associated with ...
XYY syndrome, also known as Jacobs syndrome, is an aneuploid genetic condition in which a male has an extra Y chromosome. [1] There are usually few symptoms. [2] These may include being taller than average and an increased risk of learning disabilities. [1] [2] The person is generally otherwise normal, including typical rates of fertility. [1]
In 1959, five days after Jérôme Lejeune described the trisomy-21 [3] in Down syndrome, basing himself off Marthe Gautier's work, [4] Jacobs and John Strong described an additional X chromosome in male patients (the 47,XXY karyotype) [5] also known as Klinefelter syndrome, as Harry Klinefelter had already diagnosed the symptoms in 1942.
Klinefelter syndrome (47,XXY and XXY syndrome) – a condition that describes a male born with at least one extra X chromosome. Though the most common variation is 47,XXY, a man may also be 48,XXXY or 49,XXXXY. It is a common occurrence, affecting 1 in 500 to 1,000 men. [44]