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The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
Peptic ulcer disease is when the inner part of the stomach's gastric mucosa (lining of the stomach), the first part of the small intestine, or sometimes the lower esophagus, gets damaged. An ulcer in the stomach is called a gastric ulcer , while one in the first part of the intestines is a duodenal ulcer . [ 1 ]
Mucosal disruption in acid peptic disease patients can be caused by infection, barrier disruption, or gastric acid hypersecretion.Acid peptic diseases can arise due to various risk factors such as Helicobacter pylori infection, alcoholism, tobacco use, cocaine and amphetamine use, nonsteroidal anti-inflammatory drug use (NSAIDs), fasting, Zollinger-Ellison syndrome, angiogenesis inhibitor ...
Peptic ulcer disease, an ailment commonly corrected by antrectomy. Peptic ulcer disease (PUD): The disease is characterized by ulcers developed either by impaired mucus protection or an excess of gastric acid production. [5] Antrectomy could either lead to the reduction of gastric acid levels or the removal of the peptic ulcer altogether.
Sucralfate is used for the treatment of active duodenal ulcers not related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs), as the mechanism behind these ulcers is due to acid oversecretion. [1] It is not FDA approved for gastric ulcers, but is widely used because of evidence of efficacy. [10]
Lykoudis is awarded a Greek patent (#22,453) for his antibiotic treatment of PUD. [23] 1962 Susser and Stein publish a paper identifying a cohort phenomenon of PUD in England. This is taken as evidence for stress causing PUD. [28] 1964 Lykoudis presents his antibiotic treatment for PUD at a meeting of the Medico-Surgical Society in Greece.
Peptic ulcer disease including after endoscopic treatment for bleeding [11] As part of Helicobacter pylori eradication therapy [ 12 ] Gastroesophageal reflux disease (GERD or GORD) including symptomatic endoscopy-negative reflux disease [ 13 ] and associated laryngopharyngeal reflux causing laryngitis [ 14 ] and chronic cough [ 15 ]
Peptic ulcer disease; Infections, such as tuberculosis; and infiltrative diseases, such as amyloidosis. A rare cause of gastric outlet obstruction is blockage with a gallstone, also termed "Bouveret syndrome" or "Bouveret's syndrome". In children, congenital pyloric stenosis / congenital hypertrophic pyloric stenosis may be a cause.