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Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates [5] in the ultimopharyngeal body. [6] It acts to reduce blood calcium (Ca 2+), opposing the effects of parathyroid hormone (PTH). [7]
The active vitamin D metabolite, calcitriol, exerts its biological effects by binding to the vitamin D receptor (VDR), which is primarily located in the nuclei of target cells. [ 1 ] [ 13 ] When calcitriol binds to the VDR, it enables the receptor to act as a transcription factor , modulating the gene expression of transport proteins involved ...
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
Read More: Patients Are Suing Over Alleged Side Effects of Weight-Loss Drugs. The group found that people taking the GLP-1 medications had a lower risk of a number of health conditions, including ...
A calcimimetic is a pharmaceutical drug that mimics the action of calcium on tissues, by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues.
While some added sugar can be part of a balanced diet, consuming excess amounts of added sugar has been linked with negative effects on gut health and insulin resistance, both of which can ...
CGRP mediates its effects through a heteromeric receptor composed of a G protein-coupled receptor called calcitonin receptor-like receptor and a receptor activity-modifying protein . [13] CGRP receptors are found throughout all the body, suggesting that the protein may modulate a variety of physiological functions in all major systems (e.g ...