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The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [ 1 ] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [ 2 ] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
Scientific career. Institutions. Shell Oil, Emeryville, California; University of Nebraska. Denham Harman (February 14, 1916 – November 25, 2014) was an American medical academic who latterly served as professor emeritus at the University of Nebraska Medical Center. [1][2][3] Harman is known as the " father of the free radical theory of aging ...
Antioxidant. Structure of the antioxidant glutathione. Antioxidants are compounds that inhibit oxidation (usually occurring as autoxidation), a chemical reaction that can produce free radicals. Autoxidation leads to degradation of organic compounds, including living matter. Antioxidants are frequently added to industrial products, such as ...
The free-radical theory of aging suggests that antioxidant supplements might extend human life. Reviews, however, have found that use of vitamin A (as β-carotene) and vitamin E supplements possibly can increase mortality. [118] [119] Other reviews have found no relationship between vitamin E and other vitamins with mortality. [120]
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
Lipid peroxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids, [1] resulting in the formation of peroxide and hydroperoxide derivatives. [2] It occurs when free radicals, specifically reactive oxygen species (ROS), interact with lipids within cell membranes, typically polyunsaturated fatty ...
Antioxidants really help to blunt the effect of free radical damage.” Free radicals are damaging particles generated when the body performs regular processes needed for life.
Telomere. A telomere (/ ˈtɛləmɪər, ˈtiːlə -/; from Ancient Greek τέλος (télos) 'end' and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes (see Sequences). Telomeres are a widespread genetic feature most commonly found in eukaryotes.