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  2. Vancomycin - Wikipedia

    en.wikipedia.org/wiki/Vancomycin

    But dosing guidelines from the 1980s until 2008 recommended vancomycin trough concentrations between 5 and 15 μg/mL. [37] Concern for treatment failures prompted recommendations for higher dosing (troughs 15 to 20 μg/mL) for serious infection, and acute kidney injury (AKI) rates attributable to the vancomycin increased. [38]

  3. Trough level - Wikipedia

    en.wikipedia.org/wiki/Trough_level

    In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is ...

  4. Clark's rule - Wikipedia

    en.wikipedia.org/wiki/Clark's_rule

    Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...

  5. Glycopeptide antibiotic - Wikipedia

    en.wikipedia.org/wiki/Glycopeptide_antibiotic

    Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.

  6. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]

  7. Nicole Kidman had no reservations about 'Babygirl' sex scenes ...

    www.aol.com/entertainment/nicole-kidman-had-no...

    Nicole Kidman might still be blushing over some of the scenes she filmed in her new erotic thriller Babygirl, but the film's director said the actress never wavered about the sexual material ...

  8. Crowd crush kills 35 children at funfair in Nigeria ... - AOL

    www.aol.com/crowd-crush-kills-35-children...

    At least 35 children were killed and six others critically injured in a crowd crush at a funfair in the Nigerian city of Ibadan on Wednesday, police said.

  9. Ohio Man Allegedly Slammed Infant Who Wouldn’t Stop ... - AOL

    www.aol.com/ohio-man-allegedly-slammed-infant...

    An Ohio man allegedly slammed a 15-month-old girl on the floor after she wouldn’t stop crying, fracturing her skull. Two weeks later, she died of her injuries. The man, Piqua resident Michael ...

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