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Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. [11] It is administered by intravenous injection. [11] There is also an albumin-bound formulation. [11]
Robert A. Holton (born 1944) is an American academic chemist who is known for his work regarding the chemical synthesis for Taxol (known as the Holton Taxol total synthesis), a widely utilized anti-cancer drug. He is a professor of chemistry at Florida State University.
The Holton Taxol total synthesis, published by Robert A. Holton and his group at Florida State University in 1994, was the first total synthesis of Taxol (generic name: paclitaxel). [ 1 ] [ 2 ] The Holton Taxol total synthesis is a good example of a linear synthesis .
Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). [1] This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew ( Taxus brevifolia ).
Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. [6] This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cell lung cancer. [7]
(Reuters) -The U.S. Food and Drug Administration on Tuesday approved Johnson & Johnson's chemotherapy-free combination treatment for a type of non-small cell lung cancer, setting up a challenge ...
A: Chemotherapy is effective in increasing the lifespan in some types of cancer, but it does decrease the quality of life. It may increase Oliver's lifespan for a short time, but I can understand ...
Paclitaxel was originally derived from the Pacific yew tree. [ 4 ] [ 5 ] Taxanes are difficult to synthesize because of their numerous chiral centres—taxol has 11 of these. Recently, the presence of taxanes in the shells and leaves of Corylus avellana (the common hazel plant) has been reported.