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2. Uric acid - Wikipedia

   en.wikipedia.org/wiki/Uric_acid

   Uric acid displays lactam–lactim tautomerism. [4] Uric acid crystallizes in the lactam form, [5] with computational chemistry also indicating that tautomer to be the most stable. [6] Uric acid is a diprotic acid with pK a1 = 5.4 and pK a2 = 10.3. [7] At physiological pH, urate predominates in solution. [medical citation needed]

3. Your Gout Guide: From Symptoms to Treatment - AOL

   www.aol.com/lifestyle/gout-guide-symptoms...

   Uric acid is a waste product naturally made by the body when it breaks down compounds called purines. When there’s too much uric acid in the body, it can form sharp, needle-like crystals in and ...

4. Purine metabolism - Wikipedia

   en.wikipedia.org/wiki/Purine_metabolism

   Allopurinol is a drug that inhibits the enzyme xanthine oxidoreductase and, thus, lowers the level of uric acid in the body. This may be useful in the treatment of gout, which is a disease caused by excess uric acid, forming crystals in joints.

5. Gout - Wikipedia

   en.wikipedia.org/wiki/Gout

   Naked crystals may break out of walled-off tophi due to minor physical damage to the joint, medical or surgical stress, or rapid changes in uric acid levels. [42] When they break through the tophi, they trigger a local immune-mediated inflammatory reaction in macrophages, which is initiated by the NLRP3 inflammasome protein complex.

6. Common Causes of Arthritis for Women (& How to Treat It) - AOL

   www.aol.com/common-causes-arthritis-women-treat...

   Analysis of a sample of synovial fluid to look for signs of an infection (infectious arthritis) or uric acid crystals (gout) ... Breaking down the two showdowns on Jan. 3. Sports.

7. Managing Out-of-Control Chronic Gout: Going Beyond Oral ...

   www.aol.com/lifestyle/managing-control-chronic...

   The post Managing Out-of-Control Chronic Gout: Going Beyond Oral Treatments appeared first on Reader's Digest. Do you sometimes have severe, unexplained pain in your joints, particularly in your ...