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Wild-type AAV has attracted considerable interest from gene therapy researchers due to a number of features. Chief amongst these was the virus's apparent lack of pathogenicity. It can also infect non-dividing cells and has the ability to stably integrate into the host cell genome at a specific site (designated AAVS1) in the human chromosome 19.
The Assault Amphibious Vehicle [2] [3] (AAV)—official designation AAVP-7A1 (formerly known as Landing Vehicle, Tracked, Personnel-7 abbr. LVTP-7)—is a fully tracked amphibious landing vehicle manufactured by U.S. Combat Systems (previously by United Defense, a former division of FMC Corporation).
A new gene is inserted into a cell using the AAV protein shell. Once inside the nucleus, the new gene makes functional protein to treat a disease. Alipogene tiparvovec , sold under the brand name Glybera , is a gene therapy treatment designed to reverse lipoprotein lipase deficiency (LPLD), a rare recessive disorder, due to mutations in LPL ...
On 24 November 2015, the Marines selected the BAE Systems/Iveco SuperAV, along with the SAIC Terrex, to move on to the engineering and manufacturing development phase of the ACV 1.1 program. BAE was awarded a $103.8 million contract to build 16 vehicles by late 2016 for testing, which will begin in early 2017 and last one year.
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A larger number of mRNAs would express a greater amount of protein, and how many copies of mRNA are generated depends on the promoter used in the vector. [12] The expression may be constitutive, meaning that the protein is produced constantly in the background, or it may be inducible whereby the protein is expressed only under certain condition ...
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