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The inaccuracy in Excel calculations is more complicated than errors due to a precision of 15 significant figures. Excel's storage of numbers in binary format also affects its accuracy. [ 3 ] To illustrate, the lower figure tabulates the simple addition 1 + x − 1 for several values of x .
Pearson's correlation coefficient is the covariance of the two variables divided by the product of their standard deviations. The form of the definition involves a "product moment", that is, the mean (the first moment about the origin) of the product of the mean-adjusted random variables; hence the modifier product-moment in the name.
One common use of the binomial test is the case where the null hypothesizes that two categories occur with equal frequency (: =), such as a coin toss.Tables are widely available to give the significance observed numbers of observations in the categories for this case.
For a given test, the significance criterion determines the desired degree of rigor, specifying how unlikely it is for the null hypothesis of no effect to be rejected if it is in fact true. The most commonly used threshold is a probability of rejection of 0.05, though smaller values like 0.01 or 0.001 are sometimes used.
However, the studentized range distribution used to determine the level of significance of the differences considered in Tukey's test has vastly broader application: It is useful for researchers who have searched their collected data for remarkable differences between groups, but then cannot validly determine how significant their discovered ...
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"The value for which P = .05, or 1 in 20, is 1.96 or nearly 2; it is convenient to take this point as a limit in judging whether a deviation is to be considered significant or not." [11] In Table 1 of the same work, he gave the more precise value 1.959964. [12] In 1970, the value truncated to 20 decimal places was calculated to be
In a confirmatory or primary screen with replicates, for the i-th test compound with replicates, we calculate the paired difference between the measured value (usually on the log scale) of the compound and the median value of a negative control in a plate, then obtain the mean ¯ and variance of the paired difference across replicates.
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