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Chemically, phentermine is a substituted amphetamine. [8] Phentermine was approved for medical use in the United States in 1959. [3] It is available as a generic medication. [3] In 2021, it was the 207th most commonly prescribed medication in the United States, with more than 2 million prescriptions.
Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed.
[96] [97] [98] [88] Tramadol does not inhibit the reuptake or induce the release of dopamine. [96] [88] A positron emission tomography imaging study found that single oral 50-mg and 100-mg doses of tramadol to human volunteers resulted in 34.7% and 50.2% respective mean occupation of the serotonin transporter (SERT) in the thalamus. [99]
In 2021, it was the 112th most commonly prescribed medication in the United States, with more than 5 ...
Venlafaxine. Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. [6][9] It is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. [9] Studies have shown that venlafaxine ...
Adderall. Adderall and Mydayis[10] are trade names [note 2] for a combination drug containing four salts of amphetamine. The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. [12]
Tianeptine. Tianeptine, sold under the brand names Stablon, Tatinol, and Coaxil among others, is an atypical tricyclic antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. [3][4][5] Tianeptine has antidepressant and anxiolytic ...
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