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Diaminopimelic acid (DAP) is an amino acid, representing an epsilon-carboxy derivative of lysine. meso -α,ε-Diaminopimelic acid is the last intermediate in the biosynthesis of lysine and undergoes decarboxylation by diaminopimelate decarboxylase to give the final product.
Lysine. Technically, any organic compound with an amine (–NH 2) and a carboxylic acid (–COOH) functional group is an amino acid. The proteinogenic amino acids are a small subset of this group that possess a central carbon atom (α- or 2-) bearing an amino group, a carboxyl group, a side chain and an α-hydrogen levo conformation, with the exception of glycine, which is achiral, and proline ...
The lysine/diaminopimelic acid branch of the aspartate pathway produces the essential amino acid lysine via the intermediate meso-diaminopimelic acid (meso-DAP), which is also a vital cell wall component in Gram-negative bacteria. [2] The production of dihydropicolinate from aspartate-semialdehyde controls flux into the lysine/diaminopimelic ...
The diaminopimelic acid pathway. There are two distinct lysine biosynthetic pathways: the diaminopimelic acid pathway and the α-aminoadipate pathway. The most common of the two synthetic pathways is the diaminopimelic acid pathway; it consists of several enzymatic reactions that add carbon groups to aspartate to yield lysine: [30]
Pimelic acid is the organic compound with the formula HO 2 C(CH 2) 5 CO 2 H. Pimelic acid is one CH 2 unit longer than a related dicarboxylic acid, adipic acid, a precursor to many polyesters and polyamides.
The enzyme diaminopimelate decarboxylase (EC 4.1.1.20) catalyzes the cleavage of carbon-carbon bonds in meso-2,6-diaminoheptanedioate (diaminopimelate) to produce CO 2 and L-lysine, the essential amino acid.
In enzymology, a succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) is an enzyme that catalyzes the chemical reaction. N-succinyl-LL-2,6-diaminoheptanedioate + H 2 O succinate + LL-2,6-diaminoheptanedioate
All species of Thermomonosporaceae share the same cell wall type (type III; meso-diaminopimelic acid), a similar menaquinone profile in which MK-9(H6)is predominant, and fatty acid profile type 3a. The presence of the diagnostic sugar madurose is variable, but can be found in most species of this family.