Search results
Results from the WOW.Com Content Network
A number of drugs that cause QT prolongation does not directly block hERG, but reduces the trafficking of the mature protein to the surface of the cell. This includes probucol , which appears to enhance the intercellular degradation of hERG; and several cardiac glycosides , which reduces trafficking due to decreased intracellular potassium.
Studies show topiramate causes a significant reduction in body weight. It’s unclear how exactly topiramate weight loss works, but we know that this medication can suppress your appetite and help ...
There’re at least 10 specific gene mutations that are known to be linked to Long QT syndrome, which are referred to as, for example, LQT1, LQT2, and so on, all of which have some effect on one or more ion channels. Aside from congenital causes though, sometimes the QT interval can be prolonged by certain medications which affect ion channels.
Topiramate can cause birth defects including cleft lip and palate. [12] Risk/benefit should be carefully discussed with the full treatment team. Topiramate is considered "probably compatible" with lactation and is not contraindicated in breastfeeding, though monitoring of the infant for diarrhea or poor weight gain may be considered.
Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1]
Ventricular arrhythmia, QT-prolongation. [14] Cloforex: 1969 Germany Cardiovascular toxicity. [3] Clomacron: 1982 UK Hepatotoxicity. [3] Clometacin: 1987 France Hepatotoxicity. [3] Co-proxamol (Distalgesic) 2004 UK Risk of overdose Cyclobarbital: 1980 Norway Risk of overdose [3] Cyclofenil: 1987 France Hepatotoxicity. [3] Dantron: 1963 Canada ...
The list of priapism causes goes on. Other potential offenders include: Metabolic disorders like amyloidosis. Tumors. Neurologic disorders. Cancer, including prostate, renal, and bladder cancer ...
Common causes for torsades de pointes include drug-induced QT prolongation and less often diarrhea, low serum magnesium, and low serum potassium or congenital long QT syndrome. It can be seen in malnourished individuals and chronic alcoholics , due to a deficiency in potassium and/or magnesium.