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A number of drugs that cause QT prolongation does not directly block hERG, but reduces the trafficking of the mature protein to the surface of the cell. This includes probucol , which appears to enhance the intercellular degradation of hERG; and several cardiac glycosides , which reduces trafficking due to decreased intracellular potassium.
Topiramate can cause birth defects including cleft lip and palate. [12] Risk/benefit should be carefully discussed with the full treatment team. Topiramate is considered "probably compatible" with lactation and is not contraindicated in breastfeeding, though monitoring of the infant for diarrhea or poor weight gain may be considered.
The most common medications that cause priapism are intra-cavernous injections for the treatment of erectile dysfunction (papaverine, alprostadil). Other medication groups reported are antihypertensives (e.g. Doxazosin ), antipsychotics (e.g., chlorpromazine , clozapine ), antidepressants (most notably trazodone ), anti-convulsant and mood ...
Priapism is a non-intimate prolonged arousal that isn’t relieved by climax. It is a serious medical emergency that can cause pain, lasting damage to the privates and permanent dysfunction if it ...
Erectile dysfunction can cause a “self-perpetuating cycle of anxiety and performance pressure,” says one expert. (Photo illustration: Victoria Ellis for Yahoo News; photo: ...
There’re at least 10 specific gene mutations that are known to be linked to Long QT syndrome, which are referred to as, for example, LQT1, LQT2, and so on, all of which have some effect on one or more ion channels. Aside from congenital causes though, sometimes the QT interval can be prolonged by certain medications which affect ion channels.
Unlike other SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction, [19] dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects of decreased libido (<1%) and erectile dysfunction (<4%).
Sexual dysfunction, including erectile dysfunction, loss of libido, and reduced ejaculate, may occur in 3.4 to 15.8% of men treated with finasteride or dutasteride. [19] [27] This is linked to lower quality of life and can cause stress in relationships. [28] There is also an association with lowered sexual desire. [29]
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