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  2. Pitolisant - Wikipedia

    en.wikipedia.org/wiki/Pitolisant

    Pitolisant, sold under the brand name Wakix among others, is a medication used for the treatment of excessive daytime sleepiness in adults with narcolepsy. [3] It is an inverse agonist of the histamine H 3 receptor. [3]

  3. Narcolepsy - Wikipedia

    en.wikipedia.org/wiki/Narcolepsy

    Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]

  4. Stimulant - Wikipedia

    en.wikipedia.org/wiki/Stimulant

    Pitolisant has been shown to be effective and well-tolerated for the treatment of narcolepsy with or without cataplexy. [182] [181] [180] Pitolisant is the only non-controlled anti-narcoleptic drug in the US. [180] It has shown minimal abuse risk in studies. [180] [183]

  5. Orexin - Wikipedia

    en.wikipedia.org/wiki/Orexin

    Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...

  6. Axsome's sleep disorder drug succeeds in late-stage trial ...

    www.aol.com/news/axsome-therapeutics-sleep...

    Around 70% of patients with narcolepsy also experience cataplexy episodes, according to U.S. government data, which can cause slurred speech or muscle weakness triggered by intense emotions.

  7. Solriamfetol - Wikipedia

    en.wikipedia.org/wiki/Solriamfetol

    Solriamfetol is used to promote wakefulness in the treatment of excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea in adults. [1] It appears to be more effective in improving excessive daytime sleepiness associated with obstructive sleep apnea than certain other wakefulness-promoting agents including modafinil, armodafinil, and pitolisant.

  8. Sodium oxybate - Wikipedia

    en.wikipedia.org/wiki/Sodium_oxybate

    The US label for sodium oxybate has a black box warning because it is a central nervous system depressant (CNS depressant) and for its potential for abuse.Other potential adverse side effects include respiratory depression, seizures, coma, and death, especially when it is taken in combination with other CNS depressants such as alcohol.

  9. Girl behind the viral video: Oklahoman talks about her ... - AOL

    www.aol.com/news/2015-02-04-girl-behind-the...

    Experts say cataplexy, which is a loss of muscle tone, often accompanies narcolepsy. In the video, Sarah was working on a traditional Japanese dance to send to a choreographer friend ...

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