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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
Pitolisant, sold under the brand name Wakix among others, is a medication used for the treatment of excessive daytime sleepiness in adults with narcolepsy. [3] It is an inverse agonist of the histamine H 3 receptor. [3]
Pitolisant has been shown to be effective and well-tolerated for the treatment of narcolepsy with or without cataplexy. [181] [180] [179] Pitolisant is the only non-controlled anti-narcoleptic drug in the US. [179] It has shown minimal abuse risk in studies. [179] [182]
Narcolepsy is linked to a lack of the brain chemical hypocretin , primarily produced in the hypothalamus. [26] [27] Modafinil is not a cure for narcolepsy, but it can help manage the symptoms. While modafinil is primarily used to treat excessive sleepiness, it may also help reduce the frequency and severity of cataplexy attacks in some people.
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Narcolepsy with cataplexy 347.01 G47.411 Narcolepsy without cataplexy 347.00 G47.419 Narcolepsy due to medical condition 347.10 G47.421 Narcolepsy, unspecified 347.00 G47.43 Recurrent hypersomnia 780.54 G47.13 - Kleine-Levin Syndrome: 327.13 G47.13 - Menstrual-related hypersomnia 327.13 G47.13 Idiopathic hypersomnia with long sleep time 327.11 ...
Pediatric narcolepsy cases are cases when patients are diagnosed or experience symptoms onset for narcolepsy before the age of 18. Of patients who obtain a formal diagnosis for narcolepsy, more than 50% report first experiencing symptoms of narcolepsy more than 10 years before their formal diagnosis, with an average age of symptom onset being at age 15 and symptom onset most likely to occur ...
Experts say cataplexy, which is a loss of muscle tone, often accompanies narcolepsy. In the video, Sarah was working on a traditional Japanese dance to send to a choreographer friend. "I realized ...