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Vitamin E was named "tocopherol" (from the Greek words tokos, meaning childbirth, and phero, meaning to bring forth) due to its presumed role in aiding conception. Subsequent research identified eight molecules in the vitamin E family, divided into tocopherols and tocotrienols: alpha, beta, delta, and gamma forms. [18]
The binding site for RRR-α-tocopherol is a hydrophobic pocket with a lower affinity for beta-, gamma-, or delta-tocopherols, or for the stereoisomers with an S configuration at the chiral 2 site. Tocotrienols are also a poor fit because the double bonds in the phytic tail create a rigid configuration that is a mismatch with the α-TTP pocket. [14]
Tocopherols (/ t oÊŠ ˈ k É’ f É™ ËŒ r É’ l /; [1] TCP) are a class of organic compounds comprising various methylated phenols, many of which have vitamin E activity. Because the vitamin activity was first identified in 1936 from a dietary fertility factor in rats, it was named tocopherol, from Greek τÏŒκος tókos 'birth' and φÎρειν phérein 'to bear or carry', that is 'to carry a ...
They also contain tocotrienols (a form of vitamin E), which have powerful cholesterol-lowering, anti-cancer, and neuroprotective properties. A 1-ounce (10-12 kernels) serving of macadamia nuts ...
α-Tocopherol (alpha-tocopherol) is a type of vitamin E.Its E number is "E307". Vitamin E exists in eight different forms, four tocopherols and four tocotrienols.All feature a chromane ring, with a hydroxyl group that can donate a hydrogen atom to reduce free radicals and a hydrophobic side chain, along with an aromatic ring is situated near the carbonyls in the fatty acyl chains of the ...
The liver recognizes and preferentially re-secretes α-tocopherol into circulation, making it the most abundant vitamer of vitamin E in the blood. [2] While tocotrienols are present in lower concentrations, they have more potent antioxidant properties than α-tocopherol and can have metabolic impacts at low concentration. [4]
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