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Several serious, even life-threatening diseases cause elevated serum haptocorrin, measured as abnormally high serum vitamin B 12, while at the same time potentially manifesting as a symptomatic vitamin deficiency because of insufficient vitamin bound to transcobalamin II which transfers the vitamin to cells. [56]
Found in fresh animal products (such as liver), vitamin B 12 attaches haptocorrin, which has a high affinity for its molecular structure. [5] Coupled together vitamin B 12 and haptocorrin create a complex. This haptocorrin–B 12 complex is impervious to the insult of the stomach acid, and passes on via the pylorus to the duodenum.
Hyperhomocysteinemia is a medical condition characterized by an abnormally high level of total homocysteine (that is, including homocystine and homocysteine-cysteine disulfide) in the blood, conventionally described as above 15 μmol/L. [1]
Initially in high daily doses, followed by less frequent lower doses, as the condition improves. [3] If a reversible cause is found, that cause should be corrected if possible. [11] If no reversible cause is found, or when found it cannot be eliminated, lifelong vitamin B 12 administration is usually recommended. [12] A nasal spray is also ...
Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says.
Fortunately, though, vitamin B12 isn't so hard to get enough of because it's so widely dispersed in the food supply and daily needs are relatively low. 4 Overlooked Causes of Vitamin B12 ...
Serum vitamin B 12 is a medical laboratory test that measure vitamin B 12 only in the blood binding to both transcobalamins. [1] Most of the time, 80–94% of vitamin B 12 in the blood binds to haptocorrin, while only 6–20% is binds to transcobalamin ll. [2] Only transcobalamin ll is "active" and can be used by the body. [1]
She adds that certain populations are more likely to be deficient—including vegans, because B12 is bound to animal protein in food; folks with an autoimmune disorder called pernicious anemia ...