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Heat shock proteins are also believed to play a role in the presentation of pieces of proteins (or peptides) on the cell surface to help the immune system recognize diseased cells. [22] The major HSPs involved in the HSR include HSP70, HSP90, and HSP60. [5] Chaperones include the HSP70s and HSP90s while HSP60s are considered to be chaperonins. [17]
Although stress response pathways are mediated in different ways depending on the stressor involved, cell type, etc., a general characteristic of many pathways – especially ones where heat is the principal stressor – is that they are initiated by the presence and detection of denatured proteins. Because conditions such as high temperatures ...
The heating effect varies with the power and the frequency of the electromagnetic energy, as well as the inverse square of distance to the source. The eyes and testes are particularly susceptible to radio frequency heating due to the paucity of blood flow in these areas that could otherwise dissipate the heat buildup. [7]
The effects of electromagnetic radiation upon living cells, including those in humans, depends upon the radiation's power and frequency. For low-frequency radiation (radio waves to near ultraviolet) the best-understood effects are those due to radiation power alone, acting through heating when radiation is absorbed.
The integrated stress response can be triggered within a cell due to either extrinsic or intrinsic conditions. Extrinsic factors include hypoxia, amino acid deprivation, glucose deprivation, viral infection and presence of oxidants. The main intrinsic factor is endoplasmic reticulum stress due to the accumulation of unfolded proteins.
Simplified control circuit of human thermoregulation. [8]The core temperature of a human is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system, [9] and more specifically by the anterior hypothalamic nucleus and the adjacent preoptic area regions of the hypothalamus.
The endothelium that lines blood vessels is known as vascular endothelium, which is subject to and must withstand the forces of blood flow and blood pressure from the cardiovascular system. To withstand these cardiovascular forces, endothelial cells must simultaneously have a structure capable of withstanding the forces of circulation while ...
By using the converted heat energy that ultrasound provides, specific diseased tissues can be heated often to temperatures around 41° to 45 °C. This increase in temperature has been linked to improved effectiveness of cancer treatment due to dilation of blood vessels and increased oxygen presence in affected tissues.