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The initial evidence cited by the creators of the irRC that their criteria were useful lay in the two Phase II melanoma trials described in the Clinical Cancer Research paper. The drug being trialled was a monoclonal antibody called ipilimumab , then under development at BMS with Axel Hoos as the medical lead.
Nature Reviews Disease Primers is a peer-reviewed medical journal published by Nature Portfolio.It was established in 2015. [1] The editor-in-chief is Clemens Thoma. [2] The journal publishes broad review articles about disease areas, offering a global overview of the field and outlining "key open research questions". [3]
A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. [1] A systematic review extracts and interprets data from published studies on the topic (in the scientific literature), then analyzes, describes, critically appraises and summarizes interpretations into a refined evidence-based ...
Clinical Cancer Research is a peer-reviewed medical journal on oncology, including the cellular and molecular characterization, prevention, diagnosis, and therapy of human cancer, medical and hematological oncology, radiation therapy, pediatric oncology, pathology, surgical oncology, and clinical genetics.
It builds on historical research by Gould, [18] Biagioli, [19] Spier, [11] and Rip. [20] The first Peer Review Congress met in 1989. [21] Over time, the fraction of papers devoted to peer review has steadily declined, suggesting that as a field of sociological study, it has been replaced by more systematic studies of bias and errors. [2]
Cancer research is research into cancer to identify causes and develop strategies for prevention, diagnosis, treatment, and cure. Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments.
There is a tremendous amount of research being conducted on all frontiers of oncology, ranging from cancer cell biology, and radiation therapy to chemotherapy treatment regimens and optimal palliative care and pain relief.
Two-step RT-PCR, as the name implies, occurs in two steps. First the reverse transcription and then the PCR. This method is more sensitive than the one-step method. Kits are also useful for two-step RT-PCR. Just as for one-step PCR, use only intact, high-quality RNA for the best results. The primer for two-step PCR does not have to be sequence ...