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Cannabinoid receptor 1 (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene. [5] And discovered, by determination and characterization in 1988, [6] and cloned in 1990 for the first time.
Cannabinoid receptor type 1 (CB 1) receptors are thought to be one of the most widely expressed G αi protein-coupled receptors in the brain. One mechanism through which they function is endocannabinoid-mediated depolarization-induced suppression of inhibition , a very common form of retrograde signaling , in which the depolarization of a ...
[4] [11] CB 1 antagonists produce inverse cannabimimetic effects that are opposite in direction from those produced by agonists for these receptors. [4] [16] CB 1 receptors are highly expressed in hypothalamic areas which are involved in central food intake control and feeding behavior. This strongly indicates that the cannabinoid system is ...
One of two types of cannabinoid receptors, the CB1 receptor is expressed throughout the brain at high levels. Any drug which can antagonize the CB1 receptor is referred to as a CB1 receptor antagonist.
Currently, all diesel engines offered by Volkswagen Group are direct injection (DI). This engine started as a straight-five-cylinder Audi diesel in 1989 (itself derived from the EA827 series), but got reduced to an inline-four-cylinder for Volkswagens use.
Pages in category "CB1 receptor agonists" The following 77 pages are in this category, out of 77 total. This list may not reflect recent changes. 0–9. 5F-AB-PINACA;
The Hatz Classic is a development of the Hatz CB-1. The major differences from the CB-1 are that the fuselage is more rounded, it mounts a larger engine, it uses push-pull tubes instead of control cables for the ailerons and elevators and it has aluminum ailerons. As well the seats are relocated in the fuselage and reclined to provide more leg ...
The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. [5] [6] It is closely related to the cannabinoid receptor 1 (CB1), which is largely responsible for the efficacy of endocannabinoid-mediated presynaptic-inhibition, the psychoactive properties of tetrahydrocannabinol (THC), the active agent in ...
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