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Ly6 proteins are characterized by the LU domain.Typically, they contain one LU domain, but some members of the family have multiple LU domains.The LU domain consists of 60-80 AA and contains 10 cysteines arranged in a specific pattern that allows the creation of 5 disulfide bridges which in turn allow the formation of a three-fingered (3F) structural motif.
79136 n/a Ensembl ENSG00000255552 n/a UniProt n a n/a RefSeq (mRNA) NM_001003721 NM_024123 n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene. Function LY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major ...
Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. [5] [6] [7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. [8]
The LU domain (Ly-6 antigen/uPAR) is an evolutionarily conserved protein domain of the three-finger protein superfamily. This domain is found in the extracellular domains of cell-surface receptors and in either GPI-anchored or secreted globular proteins, for example the Ly-6 family, CD59, and Sgp-2.
This gene may also play a role in the pathogenesis of psoriasis vulgaris. [5] The LYNX1 gene codes for a protein (Lynx1) that binds to acetylcholine receptors in the brain. [6] Lynx1 a member of the Ly6 superfamily of proteins that are capable of modulating neurotransmitter receptors. [7]
Gene structure is the organisation of specialised sequence elements within a gene. Genes contain most of the information necessary for living cells to survive and reproduce. [ 1 ] [ 2 ] In most organisms, genes are made of DNA, where the particular DNA sequence determines the function of the gene.
A duplication of the gene has been detected in a case study of two individuals with severe intellectual disability, suggesting its role in proper brain development and cognitive function. [10] Additionally, the protein demonstrates high expression in several other normal organs including the testis , lungs , stomach , and prostate .
[2] [3] The mRNA sequence is determined by the sequence of genomic DNA. [4] In this context, the standard genetic code is referred to as 'translation table 1' among other tables. [3] It can also be represented in a DNA codon table. The DNA codons in such tables occur on the sense DNA strand and are arranged in a 5 ′-to-3 ′ direction.