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The chicken embryo is a unique model that overcomes many limitations to studying the biology of cancer in vivo. The chorioallantoic membrane (CAM), a well-vascularized extra-embryonic tissue located underneath the eggshell, has a successful history as a biological platform for the molecular analysis of cancer including viral oncogenesis, [8] carcinogenesis, [9] tumor xenografting, [1] [10] [11 ...
Most research has been focused on chickens due to the increased threat of viral diseases within the poultry population. The innate immune response is known to be essential for viral infection and as a result, the publication of the full chicken genome sequence is a source for identifying possible adjuvants and immunity genes.
[1] [2] Thus, RSV became known as the first oncogenic retrovirus that could be used to study the development of cancer molecularly. [3] In 1958, Harry Rubin and Howard Temin developed an assay where chicken embryo fibroblasts could be altered morphologically by RSV infection. Two years later Temin concluded that the transformed morphology of ...
Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally it can infect other species of birds and mammals. [ 1 ] [ 2 ] ASLV replicates in chicken embryo fibroblasts , the cells that contribute to the formation of connective tissues.
The bone showed typical characteristics of cancer, including areas of cortical destruction, neoplastic bone formations, and disordered organization inconsistent with a simple fracture or infection. The structural and histological similarities with a high-grade human osteosarcoma case strengthened the diagnosis.
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Though the oncolytic effect of NDV was already documented in the 1950s, later advances in research into using viruses in cancer therapy came with the advent of reverse genetics technologies. [19] Later on it was Csatary LK and his colleagues to document anti-cancer effects in patients with brain gliomas. [20] [21]
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