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Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14 days after infection.
Dengue virus (DENV) is the cause of dengue fever.It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. [1] [2] Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, [3] [4] [5] all of which can cause the full spectrum of disease. [1]
Over the last twenty years, there has been a geographic spread of the disease. Dengue incidence rates have risen sharply within urban areas which have recently become endemic hot spots for the disease. [57] The recent spread of Dengue can also be attributed to rapid population growth, increased coagulation in urban areas, and global travel.
Dengue is a Flaviviridae virus, with five genetic types. [8] [9] Here is the virus drawn as a 3-dimensional model of the envelope protein. [10]Dengue is in the same family as other well known viruses carried by mosquitoes that cause tropical diseases, such as yellow fever, West Nile, and Zika virus.
Flavivirus, renamed Orthoflavivirus in 2023, [3] is a genus of positive-strand RNA viruses in the family Flaviviridae.The genus includes the West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis, [4] as well as insect-specific flaviviruses (ISFs) such as cell fusing agent virus (CFAV), Palm Creek ...
The most widely known ADE example occurs with dengue virus. [33] Dengue is a single-stranded positive-polarity RNA virus of the family Flaviviridae. It causes disease of varying severity in humans, from dengue fever (DF), which is usually self-limited, to dengue hemorrhagic fever and dengue shock syndrome, either of which may be life ...
Several articles, recent to early 2014, warn that human activities are spreading vector-borne zoonotic diseases. [ a ] Several articles were published in the medical journal The Lancet , and discuss how rapid changes in land use , trade globalization , climate change and "social upheaval" are causing a resurgence in zoonotic disease across the ...
In 1906, transmission by the Aedes mosquitoes was confirmed, and in 1907 dengue was the second disease (after yellow fever) that was shown to be caused by a virus. [42] Further investigations by John Burton Cleland and Joseph Franklin Siler completed the basic understanding of dengue transmission.