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Regular insulin, also known as neutral insulin and soluble insulin, is a type of short-acting medical insulin. [2] It is used to treat type 1 diabetes , type 2 diabetes , gestational diabetes , and complications of diabetes such as diabetic ketoacidosis and hyperosmolar hyperglycemic states . [ 5 ]
Interpretation of the resulting insulin concentrations is complex, given the numerous types of insulin available, various routes of administration, the presence of anti-insulin antibodies in insulin-dependent diabetics and the ex vivo instability of the drug. Other potential confounding factors include the wide-ranging cross-reactivity of ...
The definition of the topical route of administration sometimes states that both the application location and the pharmacodynamic effect thereof is local. [3] In other cases, topical is defined as applied to a localized area of the body or to the surface of a body part regardless of the location of the effect.
Insulin is usually given subcutaneously, either by injections or by an insulin pump.In acute care settings, insulin may also be given intravenously. Insulins are typically characterized by the rate at which they are metabolized by the body, yielding different peak times and durations of action. [4]
Conventional insulin therapy is characterized by: Insulin injections of a mixture of regular (or rapid) and intermediate acting insulin are performed two times a day, or to improve overnight glucose, mixed in the morning to cover breakfast and lunch, but with regular (or rapid) acting insulin alone for dinner and intermediate acting insulin at bedtime (instead of being mixed in at dinner).
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It is designed to improve the delivery of insulin, and is one of the earliest examples of engineered drug delivery. [3] It is used by injection under the skin once to twice a day. [1] Onset of effects is typically in 90 minutes and they last for 24 hours. [3] Versions are available that come premixed with a short-acting insulin, such as regular ...
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