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[5] [6] [7] Promethazine is taken by mouth (oral), as a rectal suppository, or by injection into a muscle (IM). [4] Common side effects of promethazine include confusion and sleepiness; [4] consumption of alcohol or other sedatives can make these symptoms worse. [4] It is unclear if use of promethazine during pregnancy or breastfeeding is safe ...
Patients under chlorpromazine showed a global improvement in symptoms and functioning. The systematic review also highlighted the fact that the side effects of the drug were 'severe and debilitating', including sedation, considerable weight gain, a lowering of blood pressure, and an increased risk of acute movement disorders. They also noted ...
Serious side effects may include movement disorders including tardive dyskinesia and neuroleptic malignant syndrome. [6] Use in pregnancy and breastfeeding is generally not recommended. [ 10 ] It is a typical antipsychotic which is believed to work by reducing the action of dopamine in the brain.
Adverse effects vary among the various agents in this class of medications, but common effects include: dry mouth, muscle stiffness, muscle cramping, tremors, EPS and weight gain. EPS refers to a cluster of symptoms consisting of akathisia , parkinsonism , and dystonia .
Side effects are not common, but the use of acepromazine in stallions should be used with caution (but is not absolutely contraindicated) due to the risk of paraphimosis and priapism. [ 6 ] Acepromazine also lowers blood pressure, and should therefore be used with caution in horses that are experiencing anemia , dehydration , shock , or colic .
Propiomazine, also known as 10-(2-dimethylaminopropyl)-2-propionylphenothiazine or as propionylpromethazine, is a phenothiazine derivative [4] and is structurally related to promethazine. The compound is provided medically as the hydrochloride and maleate salts. [6] [4] [7]
Respiratory depression is a potentially serious or fatal adverse drug reaction associated with the use of codeine, but mainly the danger lies in the much more potent and CNS-depressing phenothiazine-related antihistamine promethazine.
They are also structurally related to the tricyclic antidepressants (and tetracyclics), explaining the H 1-antihistaminergic adverse effects of those three drug classes and also the poor tolerability profile of tricyclic H 1-antihistamines. The second-generation H 1-antihistamine loratadine was derived from compounds in this group. Promethazine
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