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Dysplasia is the earliest form of precancerous lesion recognizable in a biopsy. Dysplasia can be low-grade or high-grade. High-grade dysplasia may also be referred to as carcinoma in situ. Invasive carcinoma, usually simply called cancer, has the potential to invade and spread to surrounding tissues and structures, and may eventually be lethal.
M8201/2 Cribiform carcinoma in situ (C50._) Ductal carcinoma in situ, cribiform type; M8201/3 Cribiform carcinoma, NOS Ductal carcinoma, cribiform type; M8202/0 Microcystic adenoma (C25._) M8204/0 Lactating adenoma; M8210/0 Adenomatous polyp, NOS Polypoid adenoma; M8210/2 Adenocarcinoma in situ in adenomatous polyp Adenocarcinoma in situ in ...
In HGPIN, the basal cell layer is disrupted but present. PIN is primarily found in the peripheral zone of the prostate (75-80%), rarely in the transition zone (10-15%) and very rarely in the central zone (5%), a distribution that parallels the zonal distribution for prostate carcinoma. [7]
Potentially-malignant neoplasms include carcinoma in situ. They are localised, and do not invade and destroy but in time, may transform into cancer. Malignant neoplasms are commonly called cancer. They invade and destroy the surrounding tissue, may form metastases and, if untreated or unresponsive to treatment, will generally prove fatal.
Sometimes, the term "precancer" is also used for carcinoma in situ, which is a noninvasive cancer that has not grown and spread to nearby tissue, unlike the invasive stage. As with other precancerous conditions, not all carcinoma in situ will become an invasive disease but is at risk of doing so.
2.8% [10] H&E and CK5/6 Carcinoma cells spanning entire lumen of ducts and acini [11] At least focal preservation of the basal cell layer [11] PSA+ [10] AMACR+ [10] Basal cell markers+ [10] Urothelial carcinoma 0.7 to 2.8% [12] Umbrella cells are usually present in low-grade tumors [13] Frequently branching fibrovascular cores [13] Frequently ...
The term dysplasia is typically used when the cellular abnormality is restricted to the originating tissue, as in the case of an early, in-situ neoplasm. [ citation needed ] Dysplasia, in which cell maturation and differentiation are delayed, can be contrasted with metaplasia , in which cells of one mature, differentiated type are replaced by ...
Gleason scores range from 2 to 10, with 2 representing the most well-differentiated tumors and 10 the least-differentiated tumors. Gleason scores have often been categorized into groups that show similar biologic behavior: low-grade (well-differentiated), intermediate-grade, moderate to poorly differentiated or high-grade.