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Agonists of the melatonin receptor have a number of therapeutic applications including treatment of sleep disorders and depression. The discovery and development of melatonin receptor agonists was motivated by the need for more potent analogues than melatonin, with better pharmacokinetics and longer half-lives. Melatonin receptor agonists were ...
Melatonin may be useful in the treatment of delayed sleep phase syndrome. [9] Melatonin is known to reduce jet lag, especially in eastward travel. However, if it is not taken at the correct time, it can instead delay adaptation. [30] Melatonin appears to have limited use against the sleep problems of people who work shift work. [31]
Ramelteon, sold under the brand name Rozerem among others, is a melatonin agonist medication which is used in the treatment of insomnia. [3] [5] It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset. [3] It reduces the time taken to fall asleep, but the degree of clinical benefit is small. [6]
TIK-301 (LY-156735) is an agonist for the melatonin receptors MT 1 and MT 2 that is under development for the treatment of insomnia and other sleep disorders. [1] Its agonist action on MT 1 and MT 2 receptors in the suprachiasmatic nucleus in the brain enables its action as a chronobiotic.
Piromelatine (Neu-P11) is a multimodal sleep drug under development by Neurim Pharmaceuticals. It is an agonist at melatonin MT 1 /MT 2 and serotonin 5-HT 1A /5-HT 1D receptors. Neurim is conducting a phase II randomized, placebo controlled trial of cognitive and sleep effects in Alzheimer's disease.
Agomelatine acts as a highly potent and selective melatonin MT 1 and MT 2 receptor agonist (K i = 0.1 nM and 0.12 nM, respectively) and also as a relatively weak serotonin 5-HT 2B and 5-HT 2C receptor antagonist (K i = 660 nM and 631 nM, respectively; ~6,000-fold lower than for the melatonin receptors).
Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. [1] Three types of melatonin receptors have been cloned.The MT 1 (or Mel 1A or MTNR1A) and MT 2 (or Mel 1B or MTNR1B) receptor subtypes are present in humans and other mammals, [2] while an additional melatonin receptor subtype MT 3 (or Mel 1C or MTNR1C) has been identified in amphibia and birds. [3]
Pages in category "Melatonin receptor agonists" The following 12 pages are in this category, out of 12 total. This list may not reflect recent changes. ...