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The bullae are formed by an immune reaction, initiated by the formation of IgG [citation needed] autoantibodies targeting dystonin, also called bullous pemphigoid antigen 1, [6] and/or type XVII collagen, also called bullous pemphigoid antigen 2, [7] which is a component of hemidesmosomes. A different form of dystonin is associated with ...
Homology between bullous pemphigoid antigens in the skin and neuronal antigens in the central nervous system has been proposed as a cause for the observed link between bullous pemphigoid and neurologic disease; this could be explained by an underlying genetic predisposition.
Adult linear IgA disease is an acquired, autoimmune blistering disease that may present with a clinical pattern of vesicles indistinguishable from dermatitis herpetiformis, or with vesicles and bullae in a bullous pemphigoid-like appearance. [2] This disease can often be difficult to treat even with usually effective medications such as ...
The cause of autoimmune pemphigus is generally unknown; however, certain medications have been linked to the development of pemphigus erythematosus. For example, pemphigus erythematosus flares have been linked to atorvastatin use. [8] There has been one report of a new case of pemphigus erythematosus following topical ingenol mebutate treatment ...
Note the intercellular IgG deposits in the epidermis and the early intraepidermal vesicle caused by acantholysis. Pemphigus (/ ˈ p ɛ m f ɪ ɡ ə s / or / p ɛ m ˈ f aɪ ɡ ə s /) is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. [1] The name is derived from the Greek root pemphix, meaning "blister ...
Gestational pemphigoid: IgG1: NC16A terminal of BPAG2 BPAG1: 180 230 Cicatricial pemphigoid: C-terminal of BPAG2: 180 Ocular cicatricial pemphigoid: Integrin beta-4 subunit: 200 Antiepiligrin cicatricial pemphigoid [nb 1] Laminin 5 (Epiligrin, Laminin 332) Linear IgA bullous dermatosis: LAD1 portion of BPAG2 Collagen type VII: 97 290/145 ...
From a global pandemic to signs of a looming economic recession, to most of us, stress likely feels inevitable. Layer on top of that a difficult job or tough relationships and stress becomes about ...
Antibody isotype(s) and location of antibody deposition in immunofluorescence studies using salt-split skin for autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system Condition Antibody isotype(s) deposited Localization of antibody with use of salt-split skin Antiepilegrin cicatricial pemphigoid ...