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4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid.It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. 4-Hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens ...
4-Hydroxybenzoic acid 4-O-glucoside is a glucoside of p-hydroxybenzoic acid. It can be found in mycorrhizal (Picea abies-Lactarius deterrimus and Picea abies-Laccaria amethystina) and non-mycorrhizal roots of Norway spruces (Picea abies). [1] The enzyme 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase can be found in the pollen of Pinus ...
They are produced by the esterification of para-hydroxybenzoic acid with the appropriate alcohol, such as methanol, ethanol, or n-propanol. para-Hydroxybenzoic acid is in turn produced industrially from a modification of the Kolbe-Schmitt reaction, using potassium phenoxide and carbon dioxide. [citation needed]
Hydroxybenzoic acid may refer to several related chemical compounds: 2-Hydroxybenzoic acid (salicylic acid, o-hydroxybenzoic acid) 3-Hydroxybenzoic acid (m ...
[7] [8] Hydrazone-based coupling methods are used in medical biotechnology to couple drugs to targeted antibodies (see ADC), e.g. antibodies against a certain type of cancer cell. The hydrazone-based bond is stable at neutral pH (in the blood), but is rapidly destroyed in the acidic environment of lysosomes of the cell.
Monohydroxybenzoic acid may refer to any of three isomeric phenolic acids: Salicylic acid (2-hydroxybenzoic acid, o-hydroxybenzoic acid) 3-Hydroxybenzoic acid (m-hydroxybenzoic acid) 4-Hydroxybenzoic acid (p-hydroxybenzoic acid) Monohydroxybenzoic acids can be degraded by microbes. [1]
It occurs in breast cancers at around 20.6 ± 4.2 ng/g tissue. [1] However, parabens have not been proven to cause breast cancer. [ 9 ] Estimates by the U.S. Food and Drug Administration and the Center for Food Safety and Applied Nutrition have found that the average person is exposed to about 37 ng of butylparaben per day.
Hydrazines (R 2 N−NR 2) are a class of chemical compounds with two nitrogen atoms linked via a covalent bond and which carry from one up to four alkyl or aryl substituents. . Hydrazines can be considered as derivatives of the inorganic hydrazine (H 2 N−NH 2), in which one or more hydrogen atoms have been replaced by hydrocarbon grou