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Somnifacient (from Latin somnus, sleep [1]), also known as sedatives or sleeping pills, is a class of medications that induces sleep. It is mainly used for treatment of insomnia. Examples of somnifacients include benzodiazepines, barbiturates and antihistamines. Around 2-6% of adults with insomnia use somnifacients to aid sleep. [2]
A 2017 review found that sleep onset occurred six minutes faster with use on average, but found no change in total time asleep. [14] Side effects from melatonin supplements are minimal at low doses for short durations (the studies reported about equally for both melatonin and placebo).
Ramelteon, sold under the brand name Rozerem among others, is a melatonin agonist medication which is used in the treatment of insomnia. [3] [5] It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset. [3]
Suramin is a medication used to treat African sleeping sickness and river blindness. [1] [2] It is the treatment of choice for sleeping sickness without central nervous system involvement. [3] It is given by injection into a vein. [4] Suramin causes a fair number of side effects. [4]
The weight loss drug Zepbound, generically known as tirzepatide, is also now an approved medication to treat obstructive sleep apnea, per a Food and Drug Administration Dec. 20 press release.
Although doctors recommend that adults over the age of 18 get at least 7 hours of quality sleep each night, the most recent data suggest that many may face consistent sleep issues, such as ...
Doxylamine succinate is the active ingredient in many over-the-counter sleep aids branded under various names. Doxylamine succinate and pyridoxine (Vitamin B6) are the ingredients of Diclegis, approved by the FDA in April 2013 becoming the only drug approved for morning sickness [46] with a class A safety rating for pregnancy (no evidence of risk).
Someday, the discovery might even lead to major advances in treatment. But those advances have not yet been made. All of the sleep medicine experts I interviewed emphasized that therapy and behavioral changes remain the best treatments for insomnia. Like most other sleep drugs, Belsomra provides only mild relief.