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Common side effects include nausea, vomiting, diarrhea, and loss of appetite. [3] It often turns urine, sweat, and tears a red or orange color. [3] Liver problems or allergic reactions may occur. [3] It is part of the recommended treatment of active tuberculosis during pregnancy, though its safety in pregnancy is not known. [3]
Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat tuberculosis. [1] It is a fixed dose combination of isoniazid and rifampicin (rifampin). [1] It is used together with other antituberculosis medication. [1] It is taken by mouth. [1] It is on the World Health Organization's List of Essential Medicines. [2]
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
Side effects are those of the underlying medications. [1] Pyridoxine may be used to decrease the risk of numbness. [2] It is not recommended in people with liver problems or severe kidney problems. [3] Use may not be suitable in children. [1] It is unclear if use during pregnancy is safe. [3]
Side effects are those of the underlying medications. [1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness. [2] Severe side effects include liver problems. [3] Use in those under the age of 15 may not be appropriate. [3] It is unclear if use in pregnancy is safe for the baby. [3]
Common side effects of oral antibiotics include diarrhea, resulting from disruption of the species composition in the intestinal flora, resulting, for example, in overgrowth of pathogenic bacteria, such as Clostridioides difficile. [48] Taking probiotics during the course of antibiotic treatment can help prevent antibiotic-associated diarrhea. [49]
Rifapentine in pregnant women has not been studied, but animal reproduction studies have resulted in fetal harm and were teratogenic. If rifapentine or rifampin are used in late pregnancy, coagulation should be monitored due to a possible increased risk of maternal postpartum hemorrhage and infant bleeding. [2]
Common side effects include abdominal pain, diarrhea, itchiness, dry skin, and change in skin color. [1] It can also cause swelling of the lining of the gastrointestinal tract, increased blood sugar, and sensitivity to the sun. [2] It is unclear if use during pregnancy is safe. [1]