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  2. Midodrine - Wikipedia

    en.wikipedia.org/wiki/Midodrine

    Midodrine, also known as 3,6-dimethoxy-β-hydroxy-N-aminoethanonyl-2-phenylethylamine, is a substituted phenethylamine derivative. [4] Midodrine is an odorless, white, crystalline powder, soluble in water and sparingly soluble in methanol. [19] Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95.

  3. Rectal administration - Wikipedia

    en.wikipedia.org/wiki/Rectal_administration

    Rectal administration (colloquially known as boofing or plugging) uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels, [Note 1] and flow into the body's circulatory system, which distributes the drug to the body's organs and bodily systems. [Note 2]

  4. Route of administration - Wikipedia

    en.wikipedia.org/wiki/Route_of_administration

    This can be illustrated by the action of naloxone (Narcan), an antagonist of opiates such as morphine. Naloxone counteracts opiate action in the central nervous system when given intravenously and is therefore used in the treatment of opiate overdose. The same drug, when swallowed, acts exclusively on the bowels; it is here used to treat ...

  5. Enteral administration - Wikipedia

    en.wikipedia.org/wiki/Enteral_administration

    Drugs given by enteral administration may be subjected to significant first pass metabolism, and therefore, the amount of drug entering the systemic circulation following administration may vary significantly for different individuals and drugs. Rectal administration is not subject to extensive first pass metabolism.

  6. Desglymidodrine - Wikipedia

    en.wikipedia.org/wiki/Desglymidodrine

    Desglymidodrine, also known as 3,6-dimethoxy-β-hydroxy-2-phenylethylamine, is a substituted phenethylamine derivative. [ 4 ] [ 5 ] Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95.

  7. Extended-release morphine - Wikipedia

    en.wikipedia.org/wiki/Extended-release_morphine

    MST Continus is a 12-hour release formula, therefore it is given 2 times per day. It is available in the following doses: 5 mg, 10 mg, 15 mg, 30 mg, 60 mg, 100 mg and 200 mg tablets (equating to between 0.416 mg/hour and 16.67 mg/hour).

  8. California vote count is slow, that doesn't mean it's 'rigged ...

    www.aol.com/california-vote-count-slow-doesnt...

    The claim: California counting ballots two weeks after Election Day is evidence it was ‘rigged’ A Nov. 19 Instagram post ( direct link , archive link ) claims one state’s lengthy vote ...

  9. Macy catheter - Wikipedia

    en.wikipedia.org/wiki/Macy_Catheter

    The Macy Catheter is a specialized catheter designed to provide comfortable and discreet administration of ongoing medications via the rectal route. The catheter was developed to make rectal access more practical and provide a way to deliver and retain liquid formulations in the distal rectum so that health practitioners can leverage the established benefits of rectal administration.

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