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Follicular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm.While the existence of FDC tumors was predicted by Lennert in 1978, the tumor wasn't fully recognized as its own cancer until 1986 after characterization by Monda et al. [1] [2] It accounts for only 0.4% of soft tissue sarcomas, but has significant recurrent and metastatic potential and is considered an intermediate grade ...
- Follicular dendritic cells have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane. Follicular dendritic cells ( FDC ) are cells of the immune system found in primary and secondary lymph follicles ( lymph nodes ) of the B cell areas of the lymphoid tissue .
The means by which EBV establishes a dendritic-histiocytic cell (i.e. follicular dendritic cell) infection are unclear. Follicular dendritic cells are connective tissue rather than lymphoid cells. They do, however, have a surface membrane receptor, CD21 (also known as complement receptor type 2), which EBV uses to enter B cells. EBV may escape ...
Lymph node stromal cells can give rise to a number of malignancies including: follicular dendritic cell sarcoma; fibroblastic reticular cell sarcoma; inflammatory myofibroblastic tumours and others. [9] In addition, lymph node stromal cells may produce growth factors which actively contribute to tumour cell metastasis. [10]
Clear-cell sarcoma of the kidney; Contagious reticulum cell sarcoma; D. Dermatofibrosarcoma protuberans; ... Follicular dendritic cell sarcoma; H. Hemangiosarcoma;
The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases ...
Interdigitating dendritic cell sarcoma is a form of malignant histiocytosis affecting dendritic cells. It can present in the spleen. [1]
The pattern of tumor cells radiating from a center is described as "cartwheel pattern". DFSP is a malignant tumor diagnosed with a biopsy, when a portion of the tumor is removed for examination. In order to ensure that enough tissue is removed to make an accurate diagnosis, the initial biopsy of a suspected DFSP is usually done with a core ...
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