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Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
Histamine receptors are proteins that bind with histamine, a neurotransmitter involved in various physiological processes. There are four main types: H1, H2, H3, and H4. H1 receptors are linked to allergic responses, H2 to gastric acid regulation, H3 to neurotransmitter release modulation, and H4 to immune system function.
H 2 -histamine receptor blockers can suppress the cutaneous reaction to histamine, thus resulting in to false negative results (it is recommended to discontinue the use of H 2 -histamine receptor blockers before performing diagnostic skin tests to detect an immediate allergic skin reaction). As with the use of other medicines containing bismuth ...
3274 15466 Ensembl ENSG00000113749 ENSMUSG00000034987 UniProt P25021 P97292 RefSeq (mRNA) NM_001131055 NM_022304 NM_001367711 NM_001393460 NM_001393461 NM_001010973 NM_008286 RefSeq (protein) NP_001124527 NP_001354640 NP_001010973 Location (UCSC) Chr 5: 175.66 – 175.71 Mb Chr 13: 54.35 – 54.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse H 2 receptors are a type of histamine ...
Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication. [8] It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness). [8]
An allergic reaction can be caused by direct contact with an allergen. For example, through consuming a certain food, inhalation of pollens or dust mites, or direct contact with a certain material. A family history of allergies also leads to a higher risk of developing allergic diseases. [4]
It is also used to reduce cellulite, fade wrinkles and lines, tighten loose skin, recontour the body, lighten pigmented skin, and treat alopecia, a condition that causes hair loss, according to ...
Diphenhydramine also acts as an intracellular sodium channel blocker, which is responsible for its actions as a local anesthetic. [65] Diphenhydramine has also been shown to inhibit the reuptake of serotonin. [69] It has been shown to be a potentiator of analgesia induced by morphine, but not by endogenous opioids, in rats. [70]
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