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The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
Adverse effects may include seizures, coma, addiction, and an increased risk of suicide. [7] Flashbacks may occur despite stopping usage. [8] Chemically, PCP is a member of the arylcyclohexylamine class, and pharmacologically, it is a dissociative anesthetic. [4] [9] [10] PCP works primarily as an NMDA receptor antagonist. [9]
Methadone has been shown to reduce neuropathic pain in rat models, primarily through NMDA receptor antagonism. [ citation needed ] NMDA antagonists such as dextromethorphan , ketamine , tiletamine and ibogaine are being studied for their role in decreasing the development of tolerance to opioids and as possible for eliminating addiction ...
In opioid-induced hyperalgesia, sensitization of pronociceptive mechanisms occurs, resulting in a decrease in the pain threshold, or allodynia. [10] In addition, what appears to be opioid tolerance can be caused by opioid-induced hyperalgesia lowering the baseline pain level, thus masking the drug's analgesic effects. [11]
Similar to fentanyl, a highly potent synthetic opioid, methadone stimulates opioid receptors, making it possible to overdose on the medication, said Matthew Rogalski, an addiction medicine ...
Tapentadol has been demonstrated to reduce the seizure threshold in patients. Tapentadol should be used cautiously in patients with a history of seizures, and in patients who are also taking one or more other drugs which have also been demonstrated to reduce the seizure threshold.
Not only are dogs an adorable companion but they can also be a major help when we are going through a difficult time. Puppies have been trained to use their senses to spot seizures in epileptic ...
Opioid agonist therapy (OAT) is a treatment in which prescribed opioid agonists are given to patients who live with Opioid use disorder (OUD). [1] In the case of methadone maintenance treatment (MMT), methadone is used to treat dependence on heroin or other opioids, and is administered on an ongoing basis.