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PVSRIPO, or PVS-RIPO, is the name of a modified polio virus that has recently shown promise for treating cancer. It is the focus of clinical trials being conducted at Duke University. [1] PVS-RIPO consists of a genetically modified nonpathogenic version of the oral poliovirus Sabin type 1.
In 1961, SV40 was found to cause tumors in rodents. [36] More recently, the virus was found in certain forms of cancer in humans, for instance brain and bone tumors, pleural and peritoneal mesothelioma, and some types of non-Hodgkin lymphoma. [37] [38] However, SV40 has not been determined to cause these cancers. [39]
Gromeier re-engineered the polio virus by removing a key genetic sequence. The virus can't survive this way, so he repaired the damaged with a harmless bit of cold virus. The new, modified virus, could no longer cause paralysis or death because it couldn't reproduce in normal cells. However, in a cancerous environment, this is still possible.
The virus targets the nervous system, which is why it sometimes triggers spinal and respiratory paralysis—and death. Polio primarily infects children under 5 and has done so around the globe for ...
A few could contract meningitis if the polio virus attacks the covering of the spinal cord or brain. Polio is fatal for 2%-10% of those paralyzed or between 1 in 2,000 to 1 in 10,000 of those ...
Poliomyelitis (/ ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. [1] Approximately 75% of cases are asymptomatic; [5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.
A virus that affects nerves in the spinal cord or brain stem causes polio. ... the age of 10 getting the virus, too. Treatments for polio included hot wool and physical therapy. ... the effects of ...
However, under conditions of long-term vaccine virus circulation in under-vaccinated populations, mutations can reactivate the virus to produce a polio-inducing strain, while OPV can also, in rare circumstances, induce polio or persistent asymptomatic infection in vaccinated individuals, particularly those who are immunodeficient. IPV, being ...
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