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Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse ...
Scleroderma in pregnancy is a complex situation; it increases the risk to both mother and child. [48] Overall, scleroderma is associated with reduced fetal weight for gestational age. [ 48 ] The treatment for scleroderma often includes known teratogens such as cyclophosphamide, methotrexate, mycophenolate , etc., so careful avoidance of such ...
Primary lateral sclerosis, progressive muscle weakness in the voluntary muscles. Primary sclerosing cholangitis, a hardening of the bile duct by scarring and repeated inflammation. Systemic sclerosis (progressive systemic scleroderma), a rare, chronic disease which affects the skin, and in some cases also blood vessels and internal organs.
Type III hypersensitivity, in the Gell and Coombs classification of allergic reactions, occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes.
In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. [1] [2] Any disease resulting from this type of immune response is termed an "autoimmune disease".
Nephrogenic systemic fibrosis (skin) Progressive massive fibrosis (lungs); a complication of pneumoconiosis; Retroperitoneal fibrosis (soft tissue of the retroperitoneum) Scleroderma/systemic sclerosis (skin, lungs) Some forms of adhesive capsulitis (shoulder) Fibrosis reversal. Historically, fibrosis was considered an irreversible process.
High dietary salt intake may activate a novel molecular pathway that could trigger autoimmune diseases such as multiple sclerosis (MS), a new study finds. High salt intake may trigger mechanism ...
CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc), is a multisystem connective tissue disorder. The acronym "CREST" refers to the five main features: calcinosis , Raynaud's phenomenon , esophageal dysmotility , sclerodactyly , and telangiectasia .