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Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse ...
Scleroderma in pregnancy is a complex situation; it increases the risk to both mother and child. [48] Overall, scleroderma is associated with reduced fetal weight for gestational age. [ 48 ] The treatment for scleroderma often includes known teratogens such as cyclophosphamide, methotrexate, mycophenolate , etc., so careful avoidance of such ...
CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc), is a multisystem connective tissue disorder. The acronym "CREST" refers to the five main features: calcinosis , Raynaud's phenomenon , esophageal dysmotility , sclerodactyly , and telangiectasia .
Primary lateral sclerosis, progressive muscle weakness in the voluntary muscles. Primary sclerosing cholangitis, a hardening of the bile duct by scarring and repeated inflammation. Systemic sclerosis (progressive systemic scleroderma), a rare, chronic disease which affects the skin, and in some cases also blood vessels and internal organs.
In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. [1] [2] Any disease resulting from this type of immune response is termed an "autoimmune disease".
In addition, there are other conditions that can cause TMA as a secondary manifestation; these entities include systemic lupus erythematosus (SLE), malignant hypertension, progressive systemic sclerosis (PSS, also known as scleroderma), pregnancy-associated HELLP (hemolysis, liver dysfunction, and low platelets) syndrome, and toxic drug ...
High dietary salt intake may activate a novel molecular pathway that could trigger autoimmune diseases such as multiple sclerosis (MS), a new study finds. High salt intake may trigger mechanism ...
This pathway or communication is referred to as the cervical sympathetic trunk-submandibular gland (CST-SMG) axis, a regulatory system that plays a role in the systemic control of inflammation. [ 4 ] Cellular Effects of feG: The cellular effects of the ImSAIDs are characterized in a number of publications.