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[citation needed] Annual cost to the UK National Health Service (NHS) in 2018, for 5–40 mg rosuvastatin daily (of one person) was £24-40, compared to £10-20 for 20–80 mg simvastatin. [38] In 2013, it was the fourth-highest-selling drug in the United States, accounting for approximately $5.2 billion in sales. [39]
If the maximum dose of statin cannot achieve the patient's goal, combination with ezetimibe is recommended. [17] An image of rosuvastatin tablets (Crestor) Caution. Atorvastatin and simvastatin are metabolized by CYP450 enzymes, leading to CYP450 enzymes related potential drug interactions; Contraindications. Active liver disease; Pregnancy or ...
Guidelines by the American College of Cardiology and the American Heart Association recommend statin treatment for primary prevention of cardiovascular disease in adults with LDL cholesterol ≥ 190 mg/dL (4.9 mmol/L) or those with diabetes, age 40–75 with LDL-C 70–190 mg/dL (1.8–4.9 mmol/dL); or in those with a 10-year risk of developing ...
When it comes to dosages for depression, providers typically start patients at 20 milligrams a day, with a maximum dosage of 50 milligrams. IParoxetine is intended to be used daily, although, like ...
JUPITER was a randomized double-blind placebo-controlled study investigating the use of rosuvastatin in the primary prevention of cardiovascular disease.The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP).
Drug Trade name Type Main indications Company Sales (USD millions/year) ∆ vs 2014 1 Adalimumab: Humira Biologic Rheumatoid arthritis: AbbVie Inc. 14,012 1,469 2 Ledipasvir/sofosbuvir: Harvoni Small molecule Hepatitis C: Gilead Sciences: 13,864 11,737 3 Etanercept: Enbrel Biologic Rheumatoid arthritis: Amgen. Pfizer. 8,697 4,009 4 Infliximab ...
A typical starting dosage is 200 mg per day, taken twice a day in 100 mg doses. The maximum Wellbutrin dosage is 450 mg. Wellbutrin XL is the extended-release version, ranging between 150 mg and ...
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