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May Strengthen Nails. High doses of biotin may help people with thin nails grow nails that are thicker, stronger and less brittle. However, the research on this is scant, says the NIH, so more ...
Biotin deficiency is very uncommon, but experiencing it can cause an array of side effects, including: hair thinning or loss, brittle nails, a red scaly rash (around the eyes, nose, and mouth), a ...
One important note: Excess biotin can also "cause incorrect results in certain laboratory tests that look at thyroid levels and blood markers that can help diagnose heart attacks," says Dr. Castillo.
Primary biotin deficiency, meaning deficiency as a consequence of too little biotin in the diet, is rare, because biotin is contained in so many foods. Subclinical deficiency can cause mild symptoms, such as hair thinning, brittle fingernails, or skin rash, typically on the face. [2] [4]
Decreased urinary excretion of biotin and increased urinary excretion of 3-hydroxyisovaleric acid are better indicators of biotin deficiency than concentration in the blood. [29] Rare, although biotin status can be compromised in alcoholics and during pregnancy and breastfeeding.Deficiency affects hair growth and skin health. [30] [31]
Normally, the amount of biotin in the body is regulated by dietary intake, biotin transporters (monocarboxylate transporter 1 and sodium-dependent multivitamin transporter), peptidyl hydrolase biotinidase (BTD), and the protein ligase holocarboxylase synthetase. When any of these regulatory factors are inhibited, biotin deficiency could occur. [23]
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