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  2. DAB1 - Wikipedia

    en.wikipedia.org/wiki/DAB1

    The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells . DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis .

  3. Adapter molecule crk - Wikipedia

    en.wikipedia.org/wiki/Adapter_molecule_crk

    Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction.

  4. Scrambler mouse - Wikipedia

    en.wikipedia.org/wiki/Scrambler_mouse

    The spontaneous autosomal recessive scrambler mutation on chromosome 4 causes a deficiency of DAB1, encoding disabled-1, a protein involved in the signaling of the Reelin protein, lacking in the reeler mutant, [3] Dab1-scm homozygous mutants possess a reeler-like phenotype with respect to cell malpositioning in cerebellar cortex, hippocampus, and neocortex.

  5. Reelin - Wikipedia

    en.wikipedia.org/wiki/Reelin

    5649 19699 Ensembl ENSG00000189056 ENSMUSG00000042453 UniProt P78509 Q60841 RefSeq (mRNA) NM_173054 NM_005045 NM_011261 NM_001310464 RefSeq (protein) NP_005036 NP_774959 NP_001297393 NP_035391 Location (UCSC) Chr 7: 103.47 – 103.99 Mb Chr 5: 22.09 – 22.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Reelin, encoded by the RELN gene, is a large secreted extracellular matrix ...

  6. Development of the cerebral cortex - Wikipedia

    en.wikipedia.org/wiki/Development_of_the...

    DAB1 is a regulator protein downstream of the reelin receptors. This protein is located inside cells residing in the ventricular zone, displaying highest concentrations in migrating pyramidal cells. When either reelin or DAB1 are inactivated in mice, the resulting phenotypes are the same. In this case, the neurons are unable to migrate properly ...

  7. Reeler - Wikipedia

    en.wikipedia.org/wiki/Reeler

    A reeler is a mouse mutant, so named because of its characteristic "reeling" gait.This is caused by the profound underdevelopment of the mouse's cerebellum, a segment of the brain responsible for locomotion.

  8. Cajal–Retzius cell - Wikipedia

    en.wikipedia.org/wiki/Cajal–Retzius_cell

    In early cortical development in mice, mutations of Dab1, VLDLR, and ApoER2, generate similar abnormal phenotypes, called reeler-like phenotype. It performs several abnormal processes in brain development, such as forming an outside to inside gradient, forming cells in an oblique orientation.

  9. VLDL receptor - Wikipedia

    en.wikipedia.org/wiki/VLDL_receptor

    As a result, Dab1 is tyrosine phosphorylated and reelin is degraded. Finally, phosphorylated Dab1 activates an intracellular signaling cascade that directs neuroblasts to their proper location through the alteration of the cytoskeleton. [12] [16] Many of the specifics of this pathway are still being investigated. It is not yet known if Dab1 is ...