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Styrene oxide is a main metabolite of styrene in humans or animals, resulting from oxidation by cytochrome P450. It is considered possibly carcinogenic from gavaging significant amounts into mice and rats. [4] Styrene oxide is subsequently hydrolyzed in vivo to styrene glycol by epoxide hydrolase. [5]
Styrene is regarded as a "known carcinogen", especially in case of eye contact, but also in case of skin contact, of ingestion and of inhalation, according to several sources. [20] [33] [34] [35] Styrene is largely metabolized into styrene oxide in humans, resulting from oxidation by cytochrome P450.
What is styrene used for? The major uses of styrene include making plastics, synthetic rubbers and latex paints, according to this report posted at the National Library of Medicine web site. It's ...
The styrene monomer (from which polystyrene is made) is a cancer suspect agent. [109] Styrene is "generally found in such low levels in consumer products that risks aren't substantial". [110] Polystyrene which is used for food contact may not contain more than 1% (0.5% for fatty foods) of styrene by weight. [111]
Styrene is a flammable gas and can be fatal if inhaled. The chemical is also considered a probable human carcinogen that can damage organs, inflame lungs, and make it hard to breathe, according to ...
as the first step of the aerobic styrene degradation pathway. [1] The product 2-phenyloxirane is also known as styrene oxide and can be converted by a styrene oxide isomerase (SOI) to obtain phenylacetaldehyde, which can be transformed into the key-intermediate phenylacetic acid by a phenylacetaldehyde dehydrogenase (PAD).
Officials said a chemical reaction caused styrene, which is naturally a liquid, to heat up into a gaseous state. This chemical reaction caused the tank’s pressure valve to open and release gas ...
Illustrative is the epoxidation of styrene with perbenzoic acid to styrene oxide: [12] The stereochemistry of the reaction is quite sensitive. Depending on the mechanism of the reaction and the geometry of the alkene starting material, cis and/or trans epoxide diastereomers may be formed. In addition, if there are other stereocenters present in ...