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Methyl bromoacetate is an alkylating agent. It has been used to alkylate phenol and amino groups. [4] [5] Moreover, it can be used to make vitamins and pharmaceutical drugs. It is commonly used as a reagent in chemical modification of histidine. [2] In addition, methyl bromoacetate also use in synthesize of coumarins and cis-cyclopropane.
Bromoacetic acid is the chemical compound with the formula Br C H 2 CO 2 H.This colorless solid is a relatively strong alkylating agent.Bromoacetic acid and its esters are widely used building blocks in organic synthesis, for example, in pharmaceutical chemistry.
Bromoacetone is an organic compound with the formula C H 3 COCH 2 Br. It is a colorless liquid although impure samples appear yellow or even brown. It is a colorless liquid although impure samples appear yellow or even brown.
Ethyl bromoacetate is the chemical compound with the formula Br C H 2 CO 2 CH 2 CH 3. It is the ethyl ester of bromoacetic acid and is prepared in two steps from acetic acid. [3] It is a lachrymator and has a fruity, pungent odor. [2] It is also a highly toxic alkylating agent and may be fatal if inhaled.
N-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam. It is a colorless liquid, although impure samples can appear yellow. It is miscible with water and with most common organic solvents. It also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
The mass ratio of the solvent and potassium fluoride is 1.1~2.0 : 0.5~1. When the reaction temperature of 100~160 °C is reached, methyl chloroacetate ClCH 2 CO 2 CH 3 is continuously added in the reactor at a speed of 5~10 kg/min with the mass ratio of methyl chloroacetate and potassium fluoride being 1:0.5～1. The reaction between these ...
Delamanid is sold under the brand name Deltyba, is a medication used to treat tuberculosis. [2] Specifically it is used, along with other antituberculosis medications, for active multidrug-resistant tuberculosis. [2] It is taken by mouth. [2] There are common side effects which include headache, dizziness, and nausea. [3]
Trimethylsilyl enol ethers react with NfF in the presence of a substoichiometric fluoride source at 0 °C to ambient temperature to give alkenyl nonaflates in moderate to good yields. Dried tetra-n-butylammonium fluoride was the preferred fluoride source in one study, [6] but CsF has been used in difficult cases with excellent results. [7]
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