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Bromobimane is prepared from 3,4-dimethyl-2-pyrazolin-5-one (a condensation product of ethyl 2-methylacetoacetate with hydrazine) by chlorination followed by basic treatment; with aqueous K 2 CO 3 under heterogeneous conditions, the required syn-bimane, 2,3,5,6-tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione, is the major product.
DNA Valley (or DNA Alley) [1] is a region in Maryland that serves as a biotechnology hub with a focus on genetic medicine.Roughly traced by Rockville, Frederick, and Baltimore, DNA Valley includes the innovation companies in the Maryland I-270 technology corridor, the various campuses of federal entities such as the FDA and NIH, as well as The University of Maryland, Johns Hopkins University ...