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mcg microgram: recommended replacement for "μg" which may be confused with "mg" mdi metered dose inhaler m.d.u. more dicto utendus: to be used as directed mEq milliequivalent mg milligram mg/dL milligrams per deciliter MgSO4 magnesium sulfate: may be confused with "MSO4", spell out "magnesium sulfate" midi at midday min. minimum [or] minim [or ...
K is the clearance [mL/min] or [m 3 /s] C is the concentration [mmol/L] or [mol/m 3 ] (in the United States often [mg/mL]) From the above definitions it follows that d C d t {\displaystyle {\frac {dC}{dt}}} is the first derivative of concentration with respect to time, i.e. the change in concentration with time.
The use of trapezoidal rule in AUC calculation was known in literature by no later than 1975, in J.G. Wagner's Fundamentals of Clinical Pharmacokinetics. A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics. [8]
As one can see, it would take many days for the total amount of drug within the body to come close to 1 gram (1000 mg) and achieve its full therapeutic effect. For a drug such as this, a doctor might prescribe a loading dose of one gram to be taken on the first day. That immediately gets the drug's concentration in the body up to the ...
An example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around V b l o o d = {\displaystyle V_{blood}=} 0.08 L/kg . [ 7 ] This gives a C 0 = {\displaystyle C_{0}=} 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as V b l o ...
In the metric system, a microgram or microgramme is a unit of mass equal to one millionth (1 × 10 −6) of a gram.The unit symbol is μg according to the International System of Units (SI); the recommended symbol in the United States and United Kingdom when communicating medical information is mcg.
An overview of ranges of mass. To help compare different orders of magnitude, the following lists describe various mass levels between 10 −67 kg and 10 52 kg. The least massive thing listed here is a graviton, and the most massive thing is the observable universe.
C min is a term used in pharmacokinetics for the minimum blood plasma concentration reached by a drug during a dosing interval, which is the time interval between administration of two doses. This definition is slightly different from C trough , the concentration immediately prior to administration of the next dose. [ 1 ]