Search results
Results from the WOW.Com Content Network
An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have four nuclei [5] and are 150–200 μm in diameter. When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 μm in diameter occur. These may have dozens of nuclei, and typically express major ...
The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. These are the cells responsible for the resorption of bone. Osteoblasts are generally present on the outer layer of bone, just beneath the periosteum. Attachment of the osteoclast to the osteon begins the process.
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
Osteoclasts are frequently classified and discussed separately from other MGCs which are more closely linked with disease. Non-osteoclast MGCs can arise in response to an infection, such as tuberculosis, herpes, or HIV, or as part of a foreign body reaction. These MGCs are cells of monocyte or macrophage lineage fused together.
When the gap between the bone ends is less than 0.01 mm, and interfragmentary strain is less than 2%, contact healing can occur. In this case, cutting cones, which consists of osteoclasts, form across the fracture lines, generating cavities at a rate of 50–100 μm/day.
Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification.Although osteoclasts are active during the natural formation of healthy bone the term "osteolysis" specifically refers to a pathological process.
Osteoclasts mature and/or migrate to discrete bone surfaces. Upon arrival, active enzymes, such as tartrate-resistant acid phosphatase , are secreted against the mineral substrate. [ citation needed ] The reabsorption of bone by osteoclasts also plays a role in calcium homeostasis .
Osteoclasts are multinuclear cells that are found commonly in the human body that aid in the maintenance and repair of the bones by secreting acid that dissolves bone matter. They are typically found to have 5 nuclei per cell, due to the fusion of preosteoclasts.