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In clinical trials, the most common adverse events which occurred at a rate ≥5% and ≥1.5 times placebo included paraesthesia (tingling in fingers/toes), dizziness, altered taste, insomnia, constipation, and dry mouth.
Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [44] In 1997, after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. [ 45 ]
If you need a higher dose after 90 days, your provider can prescribe up to 11.25mg of phentermine and 69mg of topiramate daily for 14 days, followed by 15mg of phentermine and 92mg of topiramate ...
Phentermine is a substituted amphetamine and topiramate has an unknown mechanism of action Approved for weight management (short-term) by the FDA but not the European Medicines Agency [ 54 ] 10% [ 55 ] or 8.25 kilograms (18.2 lb) [ 56 ]
If you need a higher dose after 90 days, your provider can prescribe up to 11.25mg of phentermine and 69mg of topiramate daily for 14 days, followed by 15mg of phentermine and 92mg of topiramate ...
Adderall and Mydayis [11] are trade names [note 2] for a combination drug containing four salts of amphetamine. The mixture is composed of equal parts racemic amphetamine and dextroamphetamine , which produces a (3:1) ratio between dextroamphetamine and levoamphetamine , the two enantiomers of amphetamine. [ 13 ]
Amphetamine mixed salts, commonly known by the trade name Adderall, continues to be produced by other manufacturers, but the FDA reports insufficient supply to meet U.S. market demand.
Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines. [9] It has also been used for alcohol dependence and essential tremor . [ 9 ]