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Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
If you need a higher dose after 90 days, your provider can prescribe up to 11.25mg of phentermine and 69mg of topiramate daily for 14 days, followed by 15mg of phentermine and 92mg of topiramate ...
Phentermine is an norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant effects. [8] [9] [10] Chemically, it is a substituted amphetamine. [11] Phentermine was approved for medical use in the United States in 1959. [3] It is available as a generic medication. [3]
Phentermine is a substituted amphetamine and topiramate has an unknown mechanism of action Approved for weight management (short-term) by the FDA but not the European Medicines Agency [ 54 ] 10% [ 55 ] or 8.25 kilograms (18.2 lb) [ 56 ]
“A doctor might recommend Tylenol over ibuprofen for patients who need pain relief but cannot tolerate NSAIDs due to stomach issues, risk of bleeding, or cardiovascular concerns,” says Walia ...
Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines. [9] It has also been used for alcohol dependence and essential tremor . [ 9 ]
A plausible mechanism involves the combined inhibition of enteric CYP3A4 and MDR1, which potentially leads to serious adverse events (e.g., nephrotoxicity). Blood levels of tacrolimus (Prograf) can also be equally affected for the same reason as ciclosporin, as both drugs are calcineurin inhibitors. [70]
A screening process refers more serious cases to professionals. For almost 20 years now, Dr. Chibanda has been using his medical training to help analyze and improve the program.