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An example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around V b l o o d = {\displaystyle V_{blood}=} 0.08 L/kg . [ 7 ] This gives a C 0 = {\displaystyle C_{0}=} 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as V b l o ...
This is a table of volume of distribution (V d) for various medication. For comparison, those with a V d L/kg body weight of less than 0.2 are mainly distributed in blood plasma, 0.2-0.7 mostly in the extracellular fluid and those with more than 0.7 are distributed throughout total body water.
Schematic illustration of idealized fiber arrays and their corresponding unit cells. In the theory of composite materials, the representative elementary volume (REV) (also called the representative volume element (RVE) or the unit cell) is the smallest volume over which a measurement can be made that will yield a value representative of the whole. [1]
The average 70 kg (150 lb) adult human body contains approximately 7 × 10 27 atoms and contains at least detectable traces of 60 chemical elements. [5] About 29 of these elements are thought to play an active positive role in life and health in humans. [6]
The blood volume is 70 ml/kg body weight in adult males, 65 ml/kg in adult females and 70-75 ml/kg in children (1 year old and over). [5] [6] Total Blood Volume has been measured manually by the use of carbon monoxide (CO) as a tracer for more than 100 years and was first proposed by French scientists Grehant and Quinquaud in 1882.
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The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time. Usually, clearance is measured in L/h or mL/min. [2] Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and ...
However, the names of all SI mass units are based on gram, rather than on kilogram; thus 10 3 kg is a megagram (10 6 g), not a *kilokilogram. The tonne (t) is an SI-compatible unit of mass equal to a megagram (Mg), or 10 3 kg. The unit is in common use for masses above about 10 3 kg and is often used with SI prefixes.