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The RNA world is a hypothetical stage in the evolutionary history of life on Earth in which self-replicating RNA molecules proliferated before the evolution of DNA and proteins. [1] The term also refers to the hypothesis that posits the existence of this stage.
RNA-based evolution is a theory that posits that RNA is not merely an intermediate between Watson and Crick model of the DNA molecule and proteins, but rather a far more dynamic and independent role-player in determining phenotype.
Kandler's pre-cell theory is supported by Wächtershäuser. [64] [65] In 1998, Carl Woese, based on the RNA world concept, proposed that no individual organism could be considered a LUCA, and that the genetic heritage of all modern organisms derived through horizontal gene transfer among an ancient community of organisms. [66]
This concept is known as the RNA world hypothesis. According to this hypothesis, the ancient RNA world transitioned into the modern cellular world via the evolution of protein synthesis, followed by replacement of many cellular ribozyme catalysts by protein-based enzymes.
In the late 1960s, Orgel proposed that life was based on RNA before it was based on DNA or proteins. His theory included genes based on RNA and RNA enzymes. [17] This view would be developed and shaped into the now widely accepted RNA world hypothesis. Almost thirty years later, Orgel wrote a lengthy review of the RNA World hypothesis. [18]
The PAH world hypothesis is a speculative hypothesis that proposes that polycyclic aromatic hydrocarbons (PAHs), known to be abundant in the universe, [173] [174] [175] including in comets, [176] and assumed to be abundant in the primordial soup of the early Earth, played a major role in the origin of life by mediating the synthesis of RNA ...
In theory, yes. Practically, we don’t know whether we could make enough of the protein in the right tissue to be therapeutic. But it’s exciting enough that scientists are working on it.
According to the RNA world hypothesis, RNA sequences performing both enzymatic and information storage roles in autocatalytic sets were an early unit of selection and evolution that would later transition into living cells. [10] It is possible that RNA-based evolution is still taking place today.